Clinical pharmacology and therapeutics, 2009-07, Vol.86 (1), p.44-48
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Efficacy of 3,4-Diaminopyridine and Pyridostigmine in the Treatment of Lambert-Eaton Myasthenic Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
- Ist Teil von
- Clinical pharmacology and therapeutics, 2009-07, Vol.86 (1), p.44-48
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2009
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- 3,4‐Diaminopyridine and pyridostigmine are widely used to treat Lambert–Eaton myasthenic syndrome (LEMS), either alone or in combination. 3,4‐Diaminopyridine enhances the release of acetylcholine at the neuromuscular synapse, and pyridostigmine inhibits the degradation of this neurotransmitter. Although this could lead to a synergistic effect on neuromuscular transmission, no studies have compared the effects of these drugs in patients with LEMS. Therefore, we performed a placebo‐controlled, double‐dummy, double‐blind, randomized, crossover study in nine patients with LEMS. Clinical Pharmacology & Therapeutics (2009); 86, 1, 44–48 doi:10.1038/clpt.2009.35
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-9236eISSN: 1532-6535DOI: 10.1038/clpt.2009.35Titel-ID: cdi_proquest_miscellaneous_67391377
- Format
- –
- Schlagworte
- 4-Aminopyridine - administration & dosage, 4-Aminopyridine - analogs & derivatives, Adult, Aged, Biological and medical sciences, Cross-Over Studies, Diseases of striated muscles. Neuromuscular diseases, Double-Blind Method, Drug Therapy, Combination, Humans, Lambert-Eaton Myasthenic Syndrome - drug therapy, Lambert-Eaton Myasthenic Syndrome - physiopathology, Medical sciences, Middle Aged, Muscle Strength - drug effects, Muscle Strength - physiology, Neurology, Pharmacology. Drug treatments, Pyridostigmine Bromide - administration & dosage, Treatment Outcome