Trends in immunology, 2009-06, Vol.30 (6), p.271-276
2009
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- Autor(en) / Beteiligte
- Titel
- Neurokinin 1 receptor isoforms and the control of innate immunity
- Ist Teil von
- Trends in immunology, 2009-06, Vol.30 (6), p.271-276
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Substance P is the prototype tachykinin peptide and triggers a variety of biological effects in both the nervous and immune system. Two naturally occurring variants of the neurokinin 1 receptor (NK1R) mediate the effects of SP: a ‘classic’ full-length receptor and a truncated (tail-less) form that lacks 96 amino acid residues at the C-terminus. Most research has focused on the full length receptor and the truncated NK1R has not been extensively explored. Recent data demonstrate that truncated NK1R has important functional roles, including modulation of responses triggered by cytokines, chemotaxis of macrophages and regulation of HIV replication. Targeting the truncated NK1R with pharmacologic agents might result in novel therapeutic approaches in diseases which affect the immune system, including HIV disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-4906eISSN: 1471-4981DOI: 10.1016/j.it.2009.03.006Titel-ID: cdi_proquest_miscellaneous_67379465
- Format
- –
- Schlagworte
- Allergy and Immunology, Alternative Splicing, Amino acids, Animals, Binding sites, Chemotaxis, Cytokines - immunology, Drug Therapy - trends, Genes, Herpes viruses, HIV Infections - drug therapy, HIV Infections - immunology, HIV-1 - pathogenicity, HIV-1 - physiology, Human immunodeficiency virus, Humans, Immune system, Immunity, Innate, Ligands, Macrophages - immunology, Protein Isoforms - physiology, Proteins, Receptors, Neurokinin-1 - physiology, Substance P - physiology, Viral infections, Virus Replication