Details

Autor(en) / Beteiligte

• Klemmensen, ÅK
• Tabor, A
• Østerdal, ML
• Knudsen, VK
• Halldorsson, TI
• Mikkelsen, TB
• Olsen, SF

Titel

Intake of vitamin C and E in pregnancy and risk of pre‐eclampsia: prospective study among 57 346 women

Ist Teil von

• BJOG : an international journal of obstetrics and gynaecology, 2009-06, Vol.116 (7), p.964-974

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2009

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Objective  It has been suggested that vitamin C, alone or in combination with vitamin E, may protect against pre‐eclampsia, whereas the safety of high‐dose vitamin E supplements has been questioned. We investigated dietary intakes of vitamins C and E to see if they correlated with the incidence of pre‐eclampsia. Design  Prospective cohort study. Setting  The Danish National Birth Cohort; a population‐based pregnancy cohort; analyses were based on 57 346 pregnancies. Methods  Vitamin intake was estimated from a food frequency questionnaire completed in gestational week 25, recording intake from diet and supplements during the previous four weeks. Pre‐eclampsia diagnoses were obtained from the Danish National Patient Registry; we worked with two entities, ‘pre‐eclampsia (all types)’ and ‘severe pre‐eclampsia/eclampsia/HELLP’. We adjusted for confounding factors by logistic regression. Main outcome measures  A small increase in the incidence of severe disease was also seen in the group of women (64, n = 49 373) with a high intake of vitamin E from supplements and dietary sources. Results  The incidence of ‘pre‐eclampsia (all types)’ did not correlate with dietary vitamin C and E intake. There was a decreasing trend (P = 0.01) in the incidence of ‘severe pre‐eclampsia/eclampsia/HELLP’ with increasing dietary vitamin C intake; with an intake of 130–170 mg/day as reference, odds ratios ranged from 1.21 (95% confidence interval 0.83 to 1.75) for an intake below 70 mg/day to 0.70 (0.40 to 1.23) for an intake exceeding 275 mg/day (total n = 57 346). For vitamin E intake aggregated from diet and supplements (n = 49 373), with an intake of 10.5–13.5 mg/day as reference, the ‘severe pre‐eclampsia/eclampsia/HELLP’ odds ratio was 1.46 (1.02 to 2.09) for an intake exceeding 18 mg/day. Conclusions  Low dietary intake of vitamin C was associated with a trend towards an increased incidence of either severe pre‐eclampsia, eclampsia or HELLP. A small increase in the incidence of severe disease was also seen in the group of women with a high intake of vitamin E from supplements and dietary sources.