Virology (New York, N.Y.), 2005-02, Vol.332 (1), p.16-19
2005
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes
- Ist Teil von
- Virology (New York, N.Y.), 2005-02, Vol.332 (1), p.16-19
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2005
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Cytotoxic T lymphocyte (CTL) senescence may be an important mechanism of immune failure in HIV-1 infection. We find that senescence of HIV-1-specific CTL clones causes loss of killing activity, preventable by transduction with telomerase. Furthermore, senescence is associated with reduced expression of the effector molecules granzyme and perforin, suggesting CTL “exhaustion” can result in hypofunction. These results agree with other studies showing that HIV-1-specific CTL exhibit abnormal phenotypes in vivo, and suggest the possibility that chronic turnover is an important mechanism of antiviral failure in HIV-1 infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0042-6822eISSN: 1096-0341DOI: 10.1016/j.virol.2004.11.028Titel-ID: cdi_proquest_miscellaneous_67366700
- Format
- –
- Schlagworte
- Aging - immunology, Cellular Senescence - immunology, Chronic Disease, Cytotoxic T lymphocytes, Granzyme B, Granzymes, HIV-1 - immunology, Human immunodeficiency virus 1, Humans, Membrane Glycoproteins - genetics, Membrane Glycoproteins - metabolism, Perforin, Pore Forming Cytotoxic Proteins, Serine Endopeptidases - genetics, Serine Endopeptidases - metabolism, T-Lymphocyte Subsets - metabolism, T-Lymphocytes, Cytotoxic - immunology, T-Lymphocytes, Cytotoxic - metabolism