Details

Autor(en) / Beteiligte

• van Wissen, Sanne
• Smilde, Tineke J.
• Trip, Mieke D.
• Stalenhoef, Anton F.H.
• Kastelein, John J.P.

Titel

Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia

Ist Teil von

• The American journal of cardiology, 2005-01, Vol.95 (2), p.264-266

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• In the 2-year Atorvastatin versus Simvastatin on Atherosclerosis Progression extension study, patients with familial hypercholesterolemia who continued to take atorvastatin 80 mg for an additional 2 years had complete arrest of the progression of mean carotid intima-media thickness (0.89 mm at the start vs 0.90 mm at the end of the study, p = 0.58). In contrast, patients previously taking simvastatin 40 mg had significant regression of intima-media thickness (0.95 mm at the start vs 0.92 mm at the end of the study, p = 0.01). Therefore, both placebo- and statin-treated patients with familial hypercholesterolemia are best treated with high-dose atorvastatin, a therapeutic regimen that induces atherosclerosis regression and is safe and well tolerated over a 4-year period.