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Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
Glia, 2005-02, Vol.49 (3), p.407-417
Li, Yi
Chen, Jieli
Zhang, Chun Ling
Wang, Lei
Lu, Dunyue
Katakowski, Mark
Gao, Qi
Shen, Li Hong
Zhang, Jing
Lu, Mei
Chopp, Michael
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Li, Yi
Chen, Jieli
Zhang, Chun Ling
Wang, Lei
Lu, Dunyue
Katakowski, Mark
Gao, Qi
Shen, Li Hong
Zhang, Jing
Lu, Mei
Chopp, Michael
Titel
Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
Ist Teil von
Glia, 2005-02, Vol.49 (3), p.407-417
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
The long‐term (4‐month) responses to treatment of stroke in the older adult rat, using rat bone marrow stromal cells (MSCs), have not been investigated. Retired breeder rats were subjected to middle cerebral artery occlusion (MCAo) alone, or injected intravenously with 3 × 106 MSCs, at 7 days after MCAo. Functional recovery was measured using an adhesive‐removal patch test and a modified neurological severity score. Bromodeoxyuridine, a cell proliferation marker, was injected daily for 14 before sacrifice. Animals were sacrificed 4 months after stroke. Double immunostaining was used to identify cell proliferation and cell types for axons, astrocytes, microglia, and oligodendrocytes. MSC treatment induced significant improvement in neurological outcome after MCAo compared with control rats. MSC treatment reduced the thickness of the scar wall (P < 0.05) and reduced the numbers of microglia/macrophages within the scar wall (P < 0.01). Double staining showed increased expression of an axonal marker (GAP‐43), among reactive astrocytes in the scar boundary zone and in the subventricular zone in the treated rats. Bromodeoxyuridine in cells preferentially colocalized with markers of astrocytes (GFAP) and oligodendrocytes (RIP) in the ipsilateral hemisphere, and gliogenesis was enhanced in the subventricular zone of the rats treated with MSCs. This is the first report to show that MSCs injected at 7 days after stroke improve long‐term neurological outcome in older animals. Brain tissue repair is an ongoing process with reactive gliosis, which persists for at least 4 months after stroke. Reactive astrocytes responding to MSC treatment of ischemia may also promote axonal regeneration during long‐term recovery. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0894-1491
eISSN: 1098-1136
DOI: 10.1002/glia.20126
Titel-ID: cdi_proquest_miscellaneous_67346362
Format
–
Schlagworte
Animals
,
Biological and medical sciences
,
bone marrow stromal cells
,
Bone Marrow Transplantation - methods
,
Brain - cytology
,
cerebral ischemia
,
functional recovery
,
Fundamental and applied biological sciences. Psychology
,
gliosis
,
Gliosis - pathology
,
Gliosis - therapy
,
Isolated neuron and nerve. Neuroglia
,
Medical sciences
,
Neurology
,
Rats
,
Rats, Wistar
,
Stroke - pathology
,
Stroke - therapy
,
Stromal Cells - cytology
,
Stromal Cells - transplantation
,
Vascular diseases and vascular malformations of the nervous system
,
Vertebrates: nervous system and sense organs
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