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Expression of urokinase plasminogen activator, its receptor and type‐1 inhibitor in malignant and benign prostate tissue
International journal of cancer, 2005-03, Vol.113 (6), p.870-880
Usher, Pernille Autzen
Thomsen, Ole Frøkjær
Iversen, Peter
Johnsen, Morten
Brünner, Nils
Høyer‐Hansen, Gunilla
Andreasen, Peter
Danø, Keld
Nielsen, Boye Schnack
2005
Details
Autor(en) / Beteiligte
Usher, Pernille Autzen
Thomsen, Ole Frøkjær
Iversen, Peter
Johnsen, Morten
Brünner, Nils
Høyer‐Hansen, Gunilla
Andreasen, Peter
Danø, Keld
Nielsen, Boye Schnack
Titel
Expression of urokinase plasminogen activator, its receptor and type‐1 inhibitor in malignant and benign prostate tissue
Ist Teil von
International journal of cancer, 2005-03, Vol.113 (6), p.870-880
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Link zum Volltext
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
The plasminogen activation (PA) cascade participates in degradation of extracellular matrix during cancer invasion. We have studied the expression of urokinase‐type plasminogen activator (uPA) mRNA, uPA receptor (uPAR) mRNA and immunoreactivity, and type‐1 plasminogen activator inhibitor (PAI‐1) mRNA and immunoreactivity in 16 prostate adenocarcinomas and 9 benign prostate hyperplasias. uPA mRNA and uPAR mRNA expression were found in 9 and 8 of the adenocarcinomas, respectively, and in 7 and 6 of the benign hyperplasias, respectively. In both malignant and benign lesions, expression of these 2 mRNAs was predominantly seen in cells identified as macrophages, which in most of the carcinomas (∼90%) were located in the interstitial tissue between the tumor cell islands, while in most of the benign hyperplasias they were located in the lumen of the glands and were in only a few cases (∼30%) found in the interstitial tissue. uPAR immunoreactivity correlated with the mRNA expression and was, in addition, found in neutrophils. PAI‐1 mRNA was detected in 13 of the 16 carcinomas and in 8 of the 9 benign hyperplasias, located in scattered fibroblast‐like cells in both groups, in some vascular structures and in a few macrophages located in the interstitial tissue of both malignant and benign lesions. A similar expression pattern was found for PAI‐1 immunoreactivity. In 8 of the 16 carcinomas, all 3 components were present, and in several areas colocalization was observed in stromal cells in close proximity to cancer cell islands. No immunoreactivity and/or mRNA expression of uPA, uPAR or PAI‐1 was observed in cancer cells or in other epithelial cells in any of the cases. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.20665
Titel-ID: cdi_proquest_miscellaneous_67345504
Format
–
Schlagworte
Adenocarcinoma - genetics
,
Adenocarcinoma - pathology
,
Biological and medical sciences
,
Carcinoma - genetics
,
Carcinoma - pathology
,
Humans
,
immunohistochemistry
,
In Situ Hybridization
,
Macrophages - pathology
,
Male
,
Medical sciences
,
Nephrology. Urinary tract diseases
,
plasminogen activation
,
Plasminogen Activator Inhibitor 1 - genetics
,
plasminogen activator inhibitor‐1 (PAI‐1)
,
Prostate - pathology
,
prostate cancer
,
Prostatic Hyperplasia - genetics
,
Prostatic Hyperplasia - pathology
,
Prostatic Neoplasms - genetics
,
Prostatic Neoplasms - pathology
,
Receptors, Cell Surface - genetics
,
Receptors, Urokinase Plasminogen Activator
,
RNA, Messenger - genetics
,
Transcription, Genetic
,
Tumors
,
Tumors of the urinary system
,
Urinary tract. Prostate gland
,
urokinase plasminogen activator (uPA)
,
urokinase plasminogen activator receptor (uPAR)
,
Urokinase-Type Plasminogen Activator - genetics
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