Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Prediagnosis Reproductive Factors and All-Cause Mortality for Women with Breast Cancer in the Breast Cancer Family Registry
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2009-06, Vol.18 (6), p.1792-1797
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
Studies have examined the prognostic relevance of reproductive factors before breast cancer diagnosis, but most have been
small and their overall findings inconclusive. Associations between reproductive risk factors and all-cause mortality after
breast cancer diagnosis were assessed with the use of a population-based cohort of 3,107 women of White European ancestry
with invasive breast cancer (1,130 from Melbourne and Sydney, Australia; 1,441 from Ontario, Canada; and 536 from Northern
California, United States). During follow-up with a median of 8.5 years, 567 deaths occurred. At recruitment, questionnaire
data were collected on oral contraceptive use, number of full-term pregnancies, age at first full-term pregnancy, time from
last full-term pregnancy to breast cancer diagnosis, breastfeeding, age at menarche, and menopause and menopausal status at
breast cancer diagnosis. Hazard ratios for all-cause mortality were estimated with the use of Cox proportional hazards models
with and without adjustment for age at diagnosis, study center, education, and body mass index. Compared with nulliparous
women, those who had a child up to 2 years, or between 2 and 5 years, before their breast cancer diagnosis were more likely
to die. The unadjusted hazard ratio estimates were 2.75 [95% confidence interval (95% CI), 1.98-3.83; P < 0.001] and 2.20 (95% CI, 1.65-2.94; P < 0.001), respectively, and the adjusted estimates were 2.25 (95% CI, 1.59-3.18; P < 0.001) and 1.82 (95% CI, 1.35-2.46; P < 0.001), respectively. When evaluating the prognosis of women recently diagnosed with breast cancer, the time since last
full-term pregnancy should be routinely considered along with other established host and tumor prognostic factors, but consideration
of other reproductive factors may not be warranted. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1792–7)