Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (2), p.373-378
2005
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Details
- Autor(en) / Beteiligte
- Titel
- A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (2), p.373-378
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- [Display omitted] A new series of γ-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2004.10.062Titel-ID: cdi_proquest_miscellaneous_67325350
- Format
- –
- Schlagworte
- Alkanes - chemical synthesis, Alkanes - pharmacology, Alzheimer Disease - drug therapy, Alzheimer Disease - metabolism, Amides - chemistry, Amines - chemistry, Amyloid Precursor Protein Secretases, Animals, Aspartic Acid Endopeptidases, Biological and medical sciences, Brain - drug effects, Brain - metabolism, Endopeptidases - metabolism, Heterocyclic Compounds - chemistry, Medical sciences, Mice, Neuropharmacology, Pharmacology. Drug treatments, Protease Inhibitors - chemical synthesis, Protease Inhibitors - pharmacology, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Structure-Activity Relationship, γ-Secretase inhibitors