Details

Autor(en) / Beteiligte

• Lee, Jiyong
• Shim, Joong Sup
• Jung, Sun-Ah
• Lee, Seung-Taek
• Kwon, Ho Jeong

Titel

N-Hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.181-183

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The discovery of a structurally new inhibitor of aminopeptidase N and its anti-angiogenic activity are reported. In the course of our screening, N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide ( 1), which contains a metal-chelating hydroxamate group, has been identified as a potent inhibitor of aminopeptidase N (APN, EC 3.4.11.2). Compound 1 potently inhibited APN activity with a K i value of 3.5 μM. It also inhibited the basic fibroblast growth-factor-induced invasion of bovine aortic endothelial cells at low micromolar concentrations.