Details

Autor(en) / Beteiligte

• Stagg, C. J
• Wylezinska, M
• Matthews, P. M
• Johansen-Berg, H
• Jezzard, P
• Rothwell, J. C
• Bestmann, S

Titel

Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy

Ist Teil von

• Journal of neurophysiology, 2009-06, Vol.101 (6), p.2872-2877

Ort / Verlag

United States: Am Phys Soc

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• 1 Centre for Functional Resonance Imaging of the Brain and 2 Department of Clinical Neurology, University of Oxford, Oxford; 3 Biological Imaging Centre, Imaging Sciences Department, MRC Clinical Sciences Centre and 4 Department of Clinical Neurosciences, Imperial College London and GSK Clinical Imaging Centre, Hammersmith Hospital; and 5 Sobell Department of Movement Neuroscience and Movement Disorders and 6 Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College, London, United Kingdom Submitted 15 September 2008; accepted in final form 24 March 2009 Continuous theta burst stimulation (cTBS) is a novel transcranial stimulation technique that causes significant inhibition of synaptic transmission for 1 h when applied over the primary motor cortex (M1) in humans. Here we use magnetic resonance spectroscopy to define mechanisms mediating this inhibition by noninvasively measuring local changes in the cortical concentrations of -aminobutyric acid (GABA) and glutamate/glutamine (Glx). cTBS to the left M1 led to an increase in GABA compared with stimulation at a control site without significant change in Glx. This direct evidence for increased GABAergic interneuronal activity is framed in terms of a new hypothesis regarding mechanisms underlying cTBS. Address for reprint requests and other correspondence: C. J. Stagg, FMRIB Centre, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK (E-mail: cstagg{at}fmrib.ox.ac.uk )