Details

Autor(en) / Beteiligte

• Zuliani, Giovanni
• Volpatol, Stefano
• Romagnoni, Franco
• Soattin, Lucia
• Bollini, Cristina
• Leoci, Vincenzo
• Fellin, Renato

Titel

Combined measurement of serum albumin and high-density lipoprotein cholesterol strongly predicts mortality in frail older nursing-home residents

Ist Teil von

• Aging clinical and experimental research, 2004-12, Vol.16 (6), p.472-475

Ort / Verlag

Germany: Springer Nature B.V

Erscheinungsjahr

2004

Quelle

SpringerLink

Beschreibungen/Notizen

• The aim of this study was to verify the hypothesis that a combined measurement of albumin and HDL-C might predict total mortality in institutionalized frail older residents. Participants were 344 older subjects (272 F, 72 M), living in the "Istituto Riposo Anziani" (I.R.A.), a nursing-home located in Padova, North-east Italy. Functional status, comorbidity, and clinical chemistry parameters were evaluated at entry. All-cause mortality was evaluated after 2 and 4 years. The sample was divided into 4 groups by using the 50 degrees percentile of albumin and HDL-C as cut-off value. The mortality odds ratio (OR) was estimated by multivariate logistic regression analysis. Total mortality was 36.8% after 2 years and 51.8% after four years. A trend toward an increase in mortality from group 1 to 4 was observed (p for trend: 0.01). The OR for 2 and 4 years mortality was 3.83 (95% CI 1.86-7.58) and 2.66 (95% CI 1.37-5.17), respectively, in group 4 compared with group 1, after adjustment for age, gender, number of chronic diseases, functional status, BMI, diabetes, dementia, stroke, CHD, CHF, hypertension, depression, COPD, and total cholesterol levels. Among frail older nursing-home residents, simple measurement of serum albumin and HDL-C levels may be useful in identifying varying degrees of frailty.