Details

Autor(en) / Beteiligte

• Zhang, Hong-wei
• Qiu, Zhi-feng
• Li, Tai-sheng

Titel

HIV-1 nef specific cytotoxic T lymphocyte responses in long-term nonprogressors and AIDS patients

Ist Teil von

• Zhong hua yi xue za zhi, 2004-12, Vol.84 (23), p.1973-1976

Ort / Verlag

China

Erscheinungsjahr

2004

Quelle

Elektronische Zeitschriftenbibliothek

Beschreibungen/Notizen

• To investigate the HIV-1 nef specific CD8(+) T cell responses in long-term nonprogressor (LTNP) and AIDS patient in China. Peripheral blood mononuclear cells were collected from 7 LTNPs and 9 AIDS patients, 12 males and 4 females, aged 37 (27 approximately 55). A panel of 26 overlapping peptides spanning HIV-1 nef constituting 3 peptide pools was used as antigens. The HIV-1 nef specific CD8(+) T cell responses of the LTNPs and AIDS patients were examined by IFN- ELISPOT assay. The amount of CD4(+) T cell and viral load were detected. The relationships between HIV-1 nef specific CD8(+) T cell responses and CD4(+) T cell counts and viral loads were studied. The strength of HIV-1 nef specific CD8(+) T cell responses of LTNP group was 404 +/- 33 SFC/10(6) PBMCs, significantly higher than that of the AIDS group (59 +/- 121 SFC/10(6) PBMCs). The strength of HIV-1 nef specific CD8(+) T cell responses was positively correlated with the CD4(+) T cell count. No relationship between the strength of CD8(+) T cell respons