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Attiki: International Institute of Anticancer Research
Erscheinungsjahr
2004
Quelle
MEDLINE
Beschreibungen/Notizen
Background: We explored the expression of Fatty Acid Synthase (FAS) in lung carcinomas and its association with clinico-pathological
features and prognosis. FAS is a recently discovered molecule involved in the energy supply of normal cells. FAS is also overexpressed
in neoplastic tissues because of their increased necessity for energy. Patients and Methods: One hundred and six patients
with non-small cell lung carcinoma were followed-up for an average period of 5 years. FAS expression was detected immunohistochemically.
Results: FAS staining was observed in 61 out of 106 cases (57.54%). Statistical analysis revealed that FAS had an overall
low prognostic value (p=0.14), while FAS-negative expression in stage I patients showed a trend for better survival (p=0.10).
PTNM stage (p<0.0001) was the only significant prognostic marker for overall survival. Conclusion: FAS is a reliable marker
of low-stage clinically aggressive lung carcinomas. The determination of FAS expression in lung carcinomas may stratify patients
and determine therapeutic approaches for their care.