Details

Autor(en) / Beteiligte

• Ostrowski, Tomasz
• Golankiewicz, Bozenna
• De Clercq, Erik
• Andrei, Graciela
• Snoeck, Robert

Titel

Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[ cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine analogues

Ist Teil von

• European journal of medicinal chemistry, 2009-08, Vol.44 (8), p.3313-3317

Ort / Verlag

Kidlington: Elsevier Masson SAS

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• A series of tricyclic analogues of acyclovir and 9-{[ cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine substituted in the 6 position with thien-2-yl, 5-bromothien-2-yl or furan-2-yl group were synthesized. The new compounds 5a– f were evaluated for their activity in vitro against varicella-zoster virus (VZV) and cytomegalovirus (CMV). The marked anti-VZV activities of 5a– f remained comparable to those of their previously described 6-phenyl-substituted counterparts. [Display omitted] A series of tricyclic analogues of acyclovir and 9-{[ cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine substituted in the 6 position were synthesized and screened for their activity in vitro against varicella-zoster virus (VZV) and cytomegalovirus (CMV).