Journal of organic chemistry, 2009-05, Vol.74 (10), p.3970-3973
2009
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Details
- Autor(en) / Beteiligte
- Titel
- A Short and Practical Synthesis of Oseltamivir Phosphate (Tamiflu) from (−)-Shikimic Acid
- Ist Teil von
- Journal of organic chemistry, 2009-05, Vol.74 (10), p.3970-3973
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Oseltamivir phosphate (1) was synthesized from (−)-shikimic acid through a short and practical synthetic route via eight steps in 47% overall yield. In addition, the highly regioselective and stereoselective nucleophilic replacement of OMs by the N3 group in the third and seventh steps has been studied in detail, and the reaction conditions were optimized.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3263eISSN: 1520-6904DOI: 10.1021/jo900218kTitel-ID: cdi_proquest_miscellaneous_67237534
- Format
- –
- Schlagworte
- Alicyclic compounds, Alicyclic compounds, terpenoids, prostaglandins, steroids, Antiviral Agents - chemical synthesis, Chemistry, Exact sciences and technology, Organic chemistry, Oseltamivir - chemical synthesis, Preparations and properties, Shikimic Acid - chemistry, Stereoisomerism