Details

Autor(en) / Beteiligte

• Singh, Brahma N.
• Singh, B.R.
• Singh, R.L.
• Prakash, D.
• Dhakarey, R.
• Upadhyay, G.
• Singh, H.B.

Titel

Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera

Ist Teil von

• Food and chemical toxicology, 2009-06, Vol.47 (6), p.1109-1116

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• The aqueous extract of leaf (LE), fruit (FE) and seed (SE) of Moringa oleifera was assessed to examine the ability to inhibit the oxidative DNA damage, antioxidant and anti-quorum sensing (QS) potentials. It was found that these extracts could significantly inhibit the OH-dependent damage of pUC18 plasmid DNA and also inhibit synergistically with trolox, with an activity sequence of LE>FE>SE. HPLC and MS/MS analysis was carried out, which showed the presence of gallic acid, chlorogenic acid, ellagic acid, ferulic acid, kaempferol, quercetin and vanillin. The LE was with comparatively higher total phenolics content (105.04mg gallic acid equivalents (GAE)/g), total flavonoids content (31.28mg quercetin equivalents (QE)/g), and ascorbic acid content (106.95mg/100g) and showed better antioxidant activity (85.77%), anti-radical power (74.3), reducing power (1.1 ascorbic acid equivalents (ASE)/ml), inhibition of lipid peroxidation, protein oxidation, OH-induced deoxyribose degradation, and scavenging power of superoxide anion and nitric oxide radicals than did the FE, SE and standard α-tocopherol. Eventually, LE and FE were found to inhibit violacein production, a QS-regulated behavior in Chromobacterium violaceum 12472.