Details

Autor(en) / Beteiligte

• Lin, Shu-Min
• Liu, Chien-Ying
• Wang, Chun-Hua
• Lin, Horng-Chyuan
• Huang, Chien-Da
• Huang, Pei-Yao
• Fang, Yueh-Fu
• Shieh, Meng-Heng
• Kuo, Han-Pin

Titel

The impact of delirium on the survival of mechanically ventilated patients

Ist Teil von

• Critical care medicine, 2004-11, Vol.32 (11), p.2254-2259

Ort / Verlag

Hagerstown, MD: by the Society of Critical Care Medicine and Lippincott Williams & Wilkins

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• OBJECTIVES:To revalidate a means of assessing delirium in intensive care unit patients and to investigate the independent effect of delirium on the mortality of mechanically ventilated patients. DESIGN:A prospective cohort study. SETTING:A 37-bed medical intensive care unit of a tertiary care hospital. PATIENTS:Subjects were 102 of 131 consecutive mechanically ventilated patients. MEASUREMENTS:All the enrolled patients were assessed for delirium using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Mortality rate were compared between patients with or without delirium, and the predictors of death were investigated. RESULTS:The two CAM-ICU assessors’ sensitivities in diagnosing delirium compared with reference standard were 91% and 95%, whereas their specificities were both 98%. They also demonstrated high interrater reliability with kappa statistics of 0.91. Delirium was present in 22 of 102 (22%) patients in the first 5 days. The delirious patients had higher intensive care unit mortality rate than nondelirious patients (63.6% vs. 32.5%, respectively), with a hazard ratio of 2.57 (95% confidence interval, 1.56–8.15). In multivariate analysis, delirium (odds ratio, 13.0; 95% confidence interval, 2.69–62.91), shock (odds ratio, 12.91; 95% confidence interval, 2.93–56.92), and illness severity (odds ratio, 9.61; 95% confidence interval, 2.24–41.18) were independent predictors of mortality. CONCLUSIONS:This study confirms previous work showing that delirium is an independent predictor for increased mortality among mechanically ventilated patients.