Details

Autor(en) / Beteiligte

• Nawata, Hajime
• Shirasawa, Senji
• Nakashima, Naoki
• Araki, Eiichi
• Hashiguchi, Jun
• Miyake, Seibei
• Yamauchi, Teruaki
• Hamaguchi, Kazuyuki
• Yoshimatsu, Hironobu
• Takeda, Haruo
• Fukushima, Hideo
• Sasahara, Takayuki
• Yamaguchi, Kohei
• Sonoda, Noriyuki
• Sonoda, Tomoko
• Matsumoto, Masahiro
• Tanaka, Yoshiya
• Sugimoto, Hidekatsu
• Tsubouchi, Hirotaka
• Inoguchi, Toyoshi
• Yanase, Toshihiko
• Wake, Nakayasu
• Narazaki, Kenziro
• Eto, Takashi
• Umeda, Fumio
• Nakazaki, Mitsuhiro
• Ono, Junko
• Asano, Takashi
• Ito, Yasuko
• Akazawa, Shoichi
• Hazegawa, Iwaho
• Takasu, Nobuyuki
• Shinohara, Moritsugu
• Nishikawa, Takeshi
• Nagafuchi, Seiho
• Okeda, Toshimitsu
• Eguchi, Katsumi
• Iwase, Masanori
• Ishikawa, Mayuko
• Aoki, Masayuki
• Keicho, Naoto
• Kato, Norihiro
• Yasuda, Kazuki
• Yamamoto, Ken
• Sasazuki, Takehiko

Titel

Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

Ist Teil von

• Journal of human genetics, 2004-11, Vol.49 (11), p.629-634

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.