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Comprehensive Analysis of Reproductive ADAMs: Relationship of ADAM4 and ADAM6 with an ADAM Complex Required for Fertilization in Mice
Ist Teil von
Biology of reproduction, 2009-05, Vol.80 (5), p.1001-1008
Ort / Verlag
United States: Society for the Study of Reproduction
Erscheinungsjahr
2009
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
A Disintegrin And Metalloprotease (ADAM) family members expressed in male reproductive tissues are divided phylogenetically
into three major groups. In the present study, we analyzed six ADAMs in one of the groups (ADAMs 4, 6, 24, 26, 29, and 30)
of which function is largely unknown. Our results showed that most of the ADAMs undergo unique processing during sperm maturation
and are located at the surface of sperm head. We found that the levels of ADAM4 and ADAM6 are dramatically reduced in Adam2 and Adam3 knockout sperm defective in various fertilization processes. We observed premature processing of ADAM4 in the Adam3 -null mice. Furthermore, we obtained a result showing complex formation of ADAM6 with ADAM2 and ADAM3 in testis. Taken together,
these results disclose involvement of ADAM4 and ADAM6 in a reproductive ADAM system that functions in fertilization.