Chung-hua wai kʿo tsa chih, 2004-10, Vol.42 (20), p.1232-1235
2004
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- Autor(en) / Beteiligte
- Titel
- Significance and role of increased expression of extracellular matrix metalloproteinase induced in the aseptic loosening of prostheses
- Ist Teil von
- Chung-hua wai kʿo tsa chih, 2004-10, Vol.42 (20), p.1232-1235
- Ort / Verlag
- China
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the expression of extracellular matrix metalloproteinase induced (EMMPRIN) in the interface tissue, and explore the role of EMMPRIN in the aseptic loosening of prostheses. Immunohistochemistry was performed to characterize the EMMPRIN-expressing cells at sites of interface tissue around aseptic loosened hip prostheses in 16 cases. Reverse transcription-polymerase chain reaction (RT-PCR) was performed to study the existence of EMMPRIN mRNA in interface tissue samples. And it was followed up by computer assisted image analysis in order to detect the A values of their expression. Synovium of hip joint of 8 femoral neck fracture were in control group. Strong immunostaining of EMMPRIN was found in the macrophages and fibroblasts of lining-like layers and vascular endothelium of synovial membrane-like interface tissue around loosened prostheses. Expression of EMMPRIN was significantly higher in interface tissue than the control synovium (z=-3.252, P=0.001). RT-PCR of interface tissue samples disclose
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0529-5815Titel-ID: cdi_proquest_miscellaneous_67173034
- Format
- –
- Schlagworte
- Adult, Aged, Arthroplasty, Replacement, Hip, Basigin - genetics, Basigin - physiology, Female, Hip Prosthesis, Humans, Immunohistochemistry, Male, Matrix Metalloproteinases - metabolism, Middle Aged, Osteolysis - physiopathology, Prosthesis Failure, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - metabolism, Synovial Membrane - metabolism