Journal of natural products (Washington, D.C.), 2004-11, Vol.67 (11), p.1796-1799
2004
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Anti-inflammatory Phloroglucinols and Terpenoids from Garcinia subelliptica
- Ist Teil von
- Journal of natural products (Washington, D.C.), 2004-11, Vol.67 (11), p.1796-1799
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Three new phloroglucinols, garcinielliptones K (1), L (2), and M (3), and two new terpenoids, garcinielliptones N (4) and O (5), have been isolated from the seeds of Garcinia subelliptica. The structures of 1-5 including their relative configurations were elucidated by spectroscopic methods and supported by computer-generated molecular modeling. Compounds 2 and 3 showed potent inhibitory effects on the release of beta-glucuronidase, and on beta-glucuronidase and histamine, respectively, from peritoneal mast cells stimulated with p-methoxy-N-methylphenethylamine (compound 48/80) in a concentration-dependent manner. Compounds 2 and 3 showed potent effects on NO production in culture media of RAW 264.7 cells in response to lipopolysaccharide (LPS). Compound 2 also showed a potent effect on NO production in culture media of N9 cells in response to LPS/interferon-gamma (IFN-gamma).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-3864eISSN: 1520-6025DOI: 10.1021/np049811xTitel-ID: cdi_proquest_miscellaneous_67134651
- Format
- –
- Schlagworte
- Animals, Anti-Inflammatory Agents, Non-Steroidal - chemistry, Anti-Inflammatory Agents, Non-Steroidal - isolation & purification, Anti-Inflammatory Agents, Non-Steroidal - pharmacology, Biological and medical sciences, Cells, Cultured, Garcinia - chemistry, General pharmacology, Interferon-gamma - metabolism, Lipopolysaccharides - metabolism, Mast Cells - drug effects, Medical sciences, Mice, Molecular Structure, Neutrophils - drug effects, Nitric Oxide - antagonists & inhibitors, Nitric Oxide - biosynthesis, Nuclear Magnetic Resonance, Biomolecular, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, Phloroglucinol - chemistry, Phloroglucinol - isolation & purification, Phloroglucinol - pharmacology, Plants, Medicinal, Taiwan, Terpenes - chemistry, Terpenes - isolation & purification, Terpenes - pharmacology, Triterpenes - chemistry, Triterpenes - isolation & purification, Triterpenes - pharmacology