Details

Autor(en) / Beteiligte

• Xu, Gang
• Jiang, Xiao-Dan
• Xu, Ying
• Zhang, Jing
• Huang, Fan-Heng
• Chen, Zhen-Zhou
• Zhou, De-Xiang
• Shang, Jiang-Hua
• Zou, Yu-Xi
• Cai, Ying-Qian
• Kou, Sheng-Bin
• Chen, Yi-Zhao
• Xu, Ru-Xiang
• Zeng, Yan-Jun

Titel

Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats

Ist Teil von

• Cell biology international, 2009-04, Vol.33 (4), p.466-474

Ort / Verlag

Oxford, UK: Elsevier Ltd

Erscheinungsjahr

2009

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Glioma is the most common primary intracranial malignant tumor. Despite advances in surgical techniques and adjuvant radio- and chemotherapies, the prognosis for patients with glioma remains poor. We have explored the effects of using genetically modified mesenchymal stem cells (MSCs) to treat malignant glioma in rats. Mesenchymal stem cells isolated from Sprague–Dawley rats can directly suppress the growth of C6 cells in vitro. MSCs transplanted intratumorally can also significantly inhibit the growth of glioma and prolong survival in C6 glioma-bearing models. MSCs producing Interleukin-18 infected by adenoviral vector inhibited glioma growth and prolonged the survival of glioma-bearing rats. Transplantation of IL-18 secreting MSCs was associated with enhanced T cell infiltration and long-term anti-tumor immunity. Thus, IL-18 may be an effective adoptive immunotherapy for malignant glioma. When used in conjunction with MSCs as targeting vehicles in vivo, IL-18 may offer a promising new treatment option for malignant glioma.