Kidney international, 2009-04, Vol.75 (8), p.771-773
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Left ventricular hypertrophy in renal disease: beyond preload and afterload
- Ist Teil von
- Kidney international, 2009-04, Vol.75 (8), p.771-773
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To explain ventricular concentric and/or eccentric hypertrophy in chronic kidney disease, past studies suggested that this was the result of increased preload and/or afterload. Using a renal ablation model of the mouse with documented absence of hypertension, Siedlecki et al. provide evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway. This suggests that load-independent primary stimuli trigger or contribute to ventricular hypertrophy and fibrosis in uremia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0085-2538eISSN: 1523-1755DOI: 10.1038/ki.2009.35Titel-ID: cdi_proquest_miscellaneous_67103186
- Format
- –
- Schlagworte
- Animals, Carrier Proteins - metabolism, Fibrosis, Humans, Hypertrophy, Left Ventricular - pathology, Hypertrophy, Left Ventricular - physiopathology, Kidney Diseases - complications, Mice, Phosphotransferases (Alcohol Group Acceptor) - metabolism, Stroke Volume, TOR Serine-Threonine Kinases, Uremia - complications