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Myelin water measurement in the spinal cord
Magnetic resonance in medicine, 2009-04, Vol.61 (4), p.883-892
Minty, Evan P.
Bjarnason, Thorarin A.
Laule, Cornelia
MacKay, Alex L.
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Minty, Evan P.
Bjarnason, Thorarin A.
Laule, Cornelia
MacKay, Alex L.
Titel
Myelin water measurement in the spinal cord
Ist Teil von
Magnetic resonance in medicine, 2009-04, Vol.61 (4), p.883-892
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
The desire to monitor the spatial–temporal characteristics of myelination in the spinal cord (SC), in the context of pathological change in demyelinating diseases or proposed neuroregenerative protocols, has led to an interest in noninvasive image‐based myelin measurement methods. We present one strategy: a magnetic resonance‐based measure that capitalizes on the characteristics of T2 relaxation of water compartmentalized within tissue. In this study, 32‐echo relaxation studies for measuring the myelin water fraction (MWF) were applied in healthy control SC in vivo using a sagittal inversion recovery multiecho sequence, and findings were supported with supplemental studies in bovine SC samples in vitro. Mean human MWF varied according the level of the SC examined: cervical, thoracic, and lumbar MWF was found to be 21.8 (SD = 2.1)%, 24.3 (3.6)%, and 11.4 (6.4)%, respectively. Noteworthy reductions were observed in areas consistent with the expected locations of the cervical and lumbar enlargements. Average bovine MWF was 30.0 (2.7)% in white matter and 8.2 (0.4)% in gray matter. The potential applications of T2 measurement in SC, both in characterizing disease processes like multiple sclerosis and in monitoring neuroregenerative therapies, should encourage future research in this area. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.21936
Titel-ID: cdi_proquest_miscellaneous_67098830
Format
–
Schlagworte
Algorithms
,
Body Water - chemistry
,
bovine
,
human
,
Magnetic Resonance Imaging - methods
,
Magnetic Resonance Spectroscopy - methods
,
Myelin Sheath - chemistry
,
myelin water
,
Reproducibility of Results
,
Sensitivity and Specificity
,
Spinal Cord - chemistry
,
spine
,
Water - analysis
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