Details

Autor(en) / Beteiligte

• Park, Beom Jin, MD, PhD
• Byun, Jae Ho, MD, PhD
• Jin, Yong Hyun, MD
• Won, Hyung Jin, MD, PhD
• Shin, Yong Moon, MD, PhD
• Kim, Kyoung Won, MD
• Park, Sang Joon, MD
• Kim, Pyo Nyun, MD, PhD

Titel

CT-guided Radiofrequency Ablation for Hepatocellular Carcinomas That Were Undetectable at US: Therapeutic Effectiveness and Safety

Ist Teil von

• Journal of vascular and interventional radiology, 2009-04, Vol.20 (4), p.490-499

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose To determine the therapeutic effectiveness and safety of computed tomography (CT)-guided radiofrequency (RF) ablation for hepatocelluar carcinomas (HCCs) that were undetectable at ultrasonography (US). Materials and Methods CT-guided RF ablation with use of internally cooled electrodes was performed in 66 patients with 97 HCCs (diameter range, 3–39 mm) in 78 sessions. Two radiologists retrospectively evaluated in consensus the presence or absence of local tumor progression as well as the complications at CT performed immediately after RF ablation and at 1-, 3-, 6-, and 12-month follow-up. The relationship between the occurrence of pneumothorax and the electrode length in the lung in patients treated with the transpulmonary approach was statistically evaluated with use of the Mann-Whitney test. Results The technical success rate of CT-guided RF ablation immediately after RF ablation was 97% (94 of 97 HCCs). The primary technique effectiveness rates of complete ablation 1, 3, 6, and 12 months after RF ablation were 97% (94 of 97 HCCs), 94% (91 of 97 HCCs), 84% (81 of 96 HCCs), and 74% (66 of 89 HCCs), respectively. Major complications were observed in six of the 78 treatment sessions (7.7%). In five of these six sessions, pneumothorax developed immediately after RF ablation; the remaining complication was tumor seeding along the electrode tract. Self-limiting pneumothorax was observed in 12 of 38 sessions (32%) in which the transpulmonary approach was used. The electrode length in the lung was not statistically related to the occurrence of pneumothorax ( P = .26). Conclusions For HCCs that are undetectable at US, CT-guided RF ablation is effective and relatively safe.