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Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells
Ist Teil von
The New England journal of medicine, 2004-11, Vol.351 (21), p.2159-2169
Ort / Verlag
Boston, MA: Massachusetts Medical Society
Erscheinungsjahr
2004
Quelle
MEDLINE
Beschreibungen/Notizen
Patients with follicular lymphoma may survive for periods ranging from less than a year to several decades. In this study, DNA-microarray analysis of gene expression in specimens of follicular lymphoma showed that two genetic signatures predicted the length of survival with a high degree of accuracy. Surprisingly, one signature consisted of genes that are typically expressed in normal T cells, and the other consisted of genes expressed in monocytes and dendritic cells.
DNA-microarray analysis of gene expression in specimens of follicular lymphoma showed that two genetic signatures predicted survival with a high degree of accuracy.
Follicular lymphoma is the second most common form of non-Hodgkin's lymphoma, accounting for about 22 percent of all cases.
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The clinical course of follicular lymphoma is variable: in some patients the disease is indolent and slowly progressive over a period of many years, with waxing and waning lymphadenopathy, whereas in others the disease progresses rapidly, often with transformation to aggressive lymphoma and early death.
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Management includes observation, chemotherapy, hematopoietic stem-cell transplantation, and immunologic therapies based on antibodies to B cells
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–
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or idiotype vaccines.
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There is no conclusive evidence that any of these approaches offers a clinically significant . . .