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Genomic characterization of human rotavirus G8 strains from the African rotavirus network: Relationship to animal rotaviruses
Journal of medical virology, 2009-05, Vol.81 (5), p.937-951
Esona, M.D.
Geyer, A.
Page, N.
Trabelsi, A.
Fodha, I.
Aminu, M.
Agbaya, V.A.
Tsion, B.
Kerin, T.K.
Armah, G.E.
Steele, A.D.
Glass, R.I.
Gentsch, J.R.
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Esona, M.D.
Geyer, A.
Page, N.
Trabelsi, A.
Fodha, I.
Aminu, M.
Agbaya, V.A.
Tsion, B.
Kerin, T.K.
Armah, G.E.
Steele, A.D.
Glass, R.I.
Gentsch, J.R.
Titel
Genomic characterization of human rotavirus G8 strains from the African rotavirus network: Relationship to animal rotaviruses
Ist Teil von
Journal of medical virology, 2009-05, Vol.81 (5), p.937-951
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Global rotavirus surveillance has led to the detection of many unusual human rotavirus (HRV) genotypes. During 1996–2004 surveillance within the African Rotavirus Network (ARN), six P[8],G8 and two P[6],G8 human rotavirus strains were identified. Gene fragments (RT‐PCR amplicons) of all 11‐gene segments of these G8 strains were sequenced in order to elucidate their genetic and evolutionary relationships. Phylogenetic and sequence analyses of each gene segment revealed high similarities (88–100% nt and 91–100% aa) for all segments except for gene 4 encoding VP4 proteins P[8] and P[6]. For most strains, almost all of the genes of the ARN strains other than neutralizing antigens are related to typical human strains of Wa genogroup. The VP7, NSP2, and NSP5 genes were closely related to cognate genes of animal strains (83–99% and 97–99% aa identity). This study suggests that the ARN G8 strains might have arisen through VP7 or VP4 gene reassortment events since most of the other gene segments resemble those of common human rotaviruses. However, VP7, NSP2 (likely), and NSP5 (likely) genes are derived potentially from animals consistent with a zoonotic introduction. Although these findings help elucidate rotavirus evolution, sequence studies of cognate animal rotavirus genes are needed to conclusively determine the specific origin of those genes relative to both human and animal rotavirus strains. J. Med. Virol. 81:937–951, 2009. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.21468
Titel-ID: cdi_proquest_miscellaneous_67084821
Format
–
Schlagworte
Africa - epidemiology
,
Animals
,
Biological and medical sciences
,
Capsid Proteins - chemistry
,
Capsid Proteins - genetics
,
characterization
,
classification
,
DNA, Viral - analysis
,
evolution
,
Evolution, Molecular
,
Fundamental and applied biological sciences. Psychology
,
Genome, Viral
,
Human rotavirus
,
Human viral diseases
,
Humans
,
Infectious diseases
,
Medical sciences
,
Microbiology
,
Miscellaneous
,
Phylogeny
,
Population Surveillance - methods
,
reassortment
,
Recombination, Genetic
,
Reverse Transcriptase Polymerase Chain Reaction
,
rotavirus
,
Rotavirus - classification
,
Rotavirus - genetics
,
Rotavirus Infections - epidemiology
,
Rotavirus Infections - virology
,
Sequence Analysis, DNA
,
Viral diseases
,
Viral Nonstructural Proteins - chemistry
,
Viral Nonstructural Proteins - genetics
,
Virology
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