Details

Autor(en) / Beteiligte

• Ba, S
• Halimi, J.-M
• Al-Najjar, A
• Barbet, C
• Buchler, M
• Brunereau, L
• Lebranchu, Y
• Tranquart, F

Titel

Prognostic Value of Absent End-Diastolic Flow Within the First Week Following Renal Transplantation

Ist Teil von

• Transplantation proceedings, 2009-03, Vol.41 (2), p.645-647

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background Doppler sonogram of the graft is used as a routine assessment in renal transplantation. When the resistance index (RI) equals 1, absent end-diastolic flow (AEDF) is observed; the prognostic value of AEDF is presently unknown. Patients and Methods Between 1988 and 1996, 342 patients received a first cadaveric kidney transplant in our ward. AEDF was observed in 30 patients who were compared with 60 controls who showed an RI < 0.75 within the first 7 days after transplantation. They were matched for year of transplantation (±1 year); recipient age (±2 years); recipient sex; and HLA antibodies (3 classes: 0%, 1–75%, >75%). The follow-up was 4 years. Results AEDF was observed at day 1 in 64%, at day 3 in 96%, and at day 7 in 28%. Recipient age, donor age, recipient sex, cold and warm ischemia durations, HLA A, B, and DR mismatches, and cytomegalovirus (CMV) status were not different between the 2 groups. Immediate graft function and 3- to 24-month creatinine levels were better in the control than the AEDF group. However, there was no difference in serum creatinine at 3 and 4 years or in patient and graft survivals during follow-up. Conclusions AEDF observed within the first week following transplantation is associated with impaired renal functional recovery. However, whether AEDF is a prognostic marker of poor long-term graft function or survival remains to be proven.