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Protein function prediction – the power of multiplicity
Ist Teil von
Trends in biotechnology (Regular ed.), 2009-04, Vol.27 (4), p.210-219
Ort / Verlag
Cambridge, MA: Elsevier Ltd
Erscheinungsjahr
2009
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Advances in experimental and computational methods have quietly ushered in a new era in protein function annotation. This ‘age of multiplicity’ is marked by the notion that only the use of multiple tools, multiple evidence and considering the multiple aspects of function can give us the broad picture that 21st century biology will need to link and alter micro- and macroscopic phenotypes. It might also help us to undo past mistakes by removing errors from our databases and prevent us from producing more. On the downside, multiplicity is often confusing. We therefore systematically review methods and resources for automated protein function prediction, looking at individual (biochemical) and contextual (network) functions, respectively.