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Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors
Ist Teil von
European journal of obstetrics & gynecology and reproductive biology, 2004-12, Vol.117 (2), p.144-147
Ort / Verlag
Shannon: Elsevier Ireland Ltd
Erscheinungsjahr
2004
Quelle
MEDLINE
Beschreibungen/Notizen
Objective: To determine to what extent adverse pregnancy outcomes are associated with thrombophilia.
Study design: We studied 31 women who had HELLP syndrome, placental abruption, fetal growth restriction or unexplained stillbirth (study group), matched with 12 controls. All women were tested for: Factor V, Prothrombin, methylenetetrahydrofolate reductase gene (
MTHFR) mutations; for Protein C, S and Antithrombin III deficiencie; for lupus anticoagulant. Correlation with 24
h BP monitoring and uterine Doppler velocimetry indexes at 22–24 weeks’ gestation was performed.
Results: Women with multiple thrombophilic factors had a significant lower birth weight (1568.33±146.8
g versus 2546.45±438
g), higher 24
h mean diastolic blood pressure at second trimester (76.3±12.5
mmHg versus 65.2±7.8
mmHg) and higher RI of uterine arteries (0.69±0.05 versus 0.50±0.15) than women with single thrombophilic factor.
Conclusion: Multiple thrombophilic factors carry a major additional risk for adverse maternal and fetal outcomes and correlate well with placental maladaptation as indicated by uterine Doppler velocimetry and 24
h BP monitoring.