Journal of child psychology and psychiatry, 2009-03, Vol.50 (3), p.317-325
2009
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Details
- Autor(en) / Beteiligte
- Titel
- The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10-14 years
- Ist Teil von
- Journal of child psychology and psychiatry, 2009-03, Vol.50 (3), p.317-325
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2009
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective. Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G‐703T and the 5‐HTTLPR) upon depressive symptoms assessed by the new CBCL/6‐18 DSM‐oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years. Results: Belonging to ‘one‐parent’ families, the TPH2 G‐703T ‘G variant’, and the 5‐HTTLPR ‘short’ alleles were associated – both alone and in apparent gene‐by‐environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while ‘family structure’ had a moderate effect size. Conclusions: A putative hazard factor impinging on individual risk at the family‐wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one‐ rather than a two‐parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9630eISSN: 1469-7610DOI: 10.1111/j.1469-7610.2008.01958.xTitel-ID: cdi_proquest_miscellaneous_67055929
- Format
- –
- Schlagworte
- Adolescent, Adult and adolescent clinical studies, Affective Behavior, affective disorders, At Risk Persons, Biological and medical sciences, Child, Child clinical studies, Child psychology, Children, Depression, Depression (Psychology), Diagnostic and Statistical Manual of Mental Disorders, divorce, Effect Size, Environment, Environmental Influences, Families & family life, family, Family Influence, Family Structure, Female, Foreign Countries, gene-environment interaction, Genetic Disorders, Genetic Predisposition to Disease, Genetics, Humans, Individual Differences, Italy, Male, Medical sciences, Mental depression, Mood disorders, Mood Disorders - diagnosis, Mood Disorders - genetics, Mood Disorders - psychology, One Parent Family, Parents, Polymorphism, Genetic - genetics, Psychology, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry, Risk factors, serotonin, Serotonin Plasma Membrane Transport Proteins - genetics, Severity of Illness Index, Surveys and Questionnaires, Symptoms (Individual Disorders), Tryptophan Hydroxylase - genetics