Current opinion in pharmacology, 2009-04, Vol.9 (2), p.109-118
2009
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- Autor(en) / Beteiligte
- Titel
- The monocyte/macrophage as a therapeutic target in atherosclerosis
- Ist Teil von
- Current opinion in pharmacology, 2009-04, Vol.9 (2), p.109-118
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- It is now clear that the monocyte/macrophage has a crucial role in the development of atherosclerosis. This cell appears to be involved in all stages of atherosclerotic plaque development and is increasingly seen as a candidate for therapeutic intervention and as a potential biomarker of disease progression and response to therapy. The main mechanisms related to the activity of the monocyte/macrophage that have been targeted for therapy are those that facilitate recruitment, cholesterol metabolism, inflammatory activity and oxidative stress. There is also increasing evidence that there is heterogeneity within the monocyte/macrophage population, which may have important implications for plaque development and regression. A better insight into how specific phenotypes may influence plaque progression should facilitate the development of novel methods of imaging and more refined treatments.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-4892eISSN: 1471-4973DOI: 10.1016/j.coph.2008.12.017Titel-ID: cdi_proquest_miscellaneous_67054873
- Format
- –
- Schlagworte
- Animals, Anti-Inflammatory Agents - therapeutic use, Antioxidants - therapeutic use, Atherosclerosis - drug therapy, Atherosclerosis - immunology, Atherosclerosis - metabolism, Cholesterol - metabolism, Clinical Trials as Topic, Drug Delivery Systems, Extracellular Matrix - metabolism, Humans, Inflammation - metabolism, Internal Medicine, Macrophages - immunology, Macrophages - metabolism, Medical Education, Models, Biological, Monocytes - immunology, Monocytes - metabolism, Oxidative Stress - immunology