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VIP hypersecretion as primary or secondary syndrome in neuroblastoma: A retrospective study by the Société Française des Cancers de l'Enfant (SFCE)
Pediatric Blood & Cancer, 2009-05, Vol.52 (5), p.585-590
Bourdeaut, Franck
de Carli, Emilie
Timsit, Sandra
Coze, Carole
Chastagner, Pascal
Sarnacki, Sabine
Delattre, Olivier
Peuchmaur, Michel
Rubie, Hervé
Michon, Jean
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Bourdeaut, Franck
de Carli, Emilie
Timsit, Sandra
Coze, Carole
Chastagner, Pascal
Sarnacki, Sabine
Delattre, Olivier
Peuchmaur, Michel
Rubie, Hervé
Michon, Jean
Titel
VIP hypersecretion as primary or secondary syndrome in neuroblastoma: A retrospective study by the Société Française des Cancers de l'Enfant (SFCE)
Ist Teil von
Pediatric Blood & Cancer, 2009-05, Vol.52 (5), p.585-590
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
Background Neuroblastic tumors (NTs) are occasionally associated with watery diarrhea, due to Vasoactive Intestinal Peptide (VIP) secretion. Most reports are single cases and suggest a great homogeny within this sub‐group of NTs. Procedures We conducted a retrospective analysis of the French experience of NTs associated with watery diarrhea due to VIP‐secretion. VIP secretion was confirmed by seric dosage and/or immunohistochemistry. Results Twenty‐two patients met the diagnostic criteria between 1988 and 2007. Most of patients suffered from weight loss and metabolic disorders. In 16 cases, digestive symptoms preceded the diagnosis of the tumor (“Primary VIP secreting NTs”); 15 were localized and all showed a differentiated histology. Interestingly, in another 6 patients with high‐risk NT, diarrhea occurred at the time of chemotherapy or retinoic acid therapy (“Secondary VIP secreting NTs”). Differentiation in response to treatment was documented in 4 cases. In all cases, only surgical excision of the tumor was able to control the digestive symptoms. Twenty children are alive and 13 are disease‐free. Conclusion VIP secreting NTs are usually associated with differentiation; they can also secondarily arise from a high‐risk tumor upon treatment. Primary surgery constitutes first‐line treatment. Pediatr Blood Cancer 2009;52:585–590. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1545-5009
eISSN: 1545-5017, 1096-911X
DOI: 10.1002/pbc.21912
Titel-ID: cdi_proquest_miscellaneous_67054057
Format
–
Schlagworte
Child, Preschool
,
diarrhea
,
differentiation
,
Disease-Free Survival
,
Female
,
France
,
Humans
,
Infant
,
Male
,
neuroblastoma
,
Neuroblastoma - enzymology
,
Neuroblastoma - pathology
,
Neuroblastoma - secondary
,
Neuroblastoma - secretion
,
Retrospective Studies
,
Societies, Medical
,
Survival Rate
,
vasoactive intestinal peptide
,
Vasoactive Intestinal Peptide - secretion
,
WDHA syndrome
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