Details

Autor(en) / Beteiligte

• Ruggeri, Loredana
• Capanni, Marusca
• Mancusi, Antonella
• Urbani, Elena
• Perruccio, Katia
• Burchielli, Emanuela
• Tosti, Antonella
• Topini, Fabiana
• Aversa, Franco
• Martelli, Massimo F.
• Velardi, Andrea

Titel

Alloreactive natural killer cells in mismatched hematopoietic stem cell transplantation

Ist Teil von

• Blood cells, molecules, & diseases, 2004-11, Vol.33 (3), p.216-221

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Natural killer (NK) cell-mediated, donor-vs.-recipient alloresponses occur following transplantation of human leukocyte antigen (HLA) haplotype-mismatched hematopoietic stem cells (HSCs). NK cell alloreactivity reduced the risk of relapse in acute myeloid leukemia patients while improving engraftment and protecting against graft-vs.-host disease (GvHD). NK cells are primed to kill by several activating receptors. NK killing of autologous cells is prevented because NK cells co-express inhibitory receptors (killer cell Ig-like receptors, KIR) that recognize groups of (self) MHC class I alleles. As KIRs are clonally distributed, the NK population in any individual is constituted of a repertoire with different allospecificities. NK cells in the repertoire mediate alloreactions when the allogeneic targets do not express class I alleles that block them. High resolution molecular HLA typing of recipient and donor, positive identification of donor KIR genes, and in some cases, functional assessment of donor NK clones will identify haploidentical donors who are able to mount donor-vs.-recipient NK alloreactions.