Details

Autor(en) / Beteiligte

• Tabaouti, K
• Kraoul, L
• Alyousef, L
• Lahoud, G Abi
• Rousset, S Brovedani
• Lancelin, F
• Mouchet, E
• Piketty, M-L

Titel

The role of biology in the diagnosis of cerebrospinal fluid leaks

Ist Teil von

• Annales de biologie clinique (Paris), 2009-03, Vol.67 (2), p.141-151

Ort / Verlag

France

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Cerebrospinal fluid leakage is a rare but critical condition with a substantial risk of intracranial infection, therefore its diagnosis and treatment is of major importance. CSF leakage diagnostic can be a challenging problem. Nephelometric measurement of beta-trace protein in the liquorrhoea is a non-invasive and fast method that can be used for CSF leakage diagnosis. It should kept in mind, however, that the cut-off of 1.1 mg/L is not suitable for patients with bacterial meningitis and those with a reduced glomerular filtration rate. Complementary use of beta-trace protein assay and beta2-transferrin detection is therefore recommended.