Details

Autor(en) / Beteiligte

• Vasku, Julie Anna
• Vasku, Anna
• Goldbergova, Monika
• Vasku, Vladimir

Titel

Heterozygote AG variant of −596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)

Ist Teil von

• Clinical immunology (Orlando, Fla.), 2004-12, Vol.113 (3), p.256-260

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

2004

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• The aim of the study was to investigate possible associations of IL-6 gene polymorphisms (−596 A/G and −174 C/G) with cutaneous T-cell lymphoma (CTCL). In the case-control study, genotype distributions and allelic frequencies in two promoter IL-6 gene polymorphisms in the group of 63 Czech patients with CTCL were compared to those of 105 control non-CTCL subjects matched for age and sex. The IL-6 gene polymorphisms were determined by PCR with following restriction analysis. A significant difference of −596 A/G IL-6 genotype distribution was found between the CTCL patients and the controls ( P = 0.002) with almost threefold odds ratio for the heterozygote (AG) genotype in CTCL patients (OR = 2.64, P = 0.002). No significant differences in genotype distribution and/or allelic frequency of functional −174 C/G IL-6 gene polymorphism were observed. The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with CTCL (OR = 2.24, 95% confidence interval 1.17–4.28, P = 0.01). Thus, the heterozygote variant of −596 A/G promoter IL-6 polymorphism could be considered as a genotype marker for CTCL.