Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Heat shock protein 27 protects the heart against myocardial infarction
Ist Teil von
Basic research in cardiology, 2004-11, Vol.99 (6), p.392-394
Ort / Verlag
Germany: Springer Nature B.V
Erscheinungsjahr
2004
Link zum Volltext
Quelle
SpringerLink
Beschreibungen/Notizen
Heat shock proteins (hsp) represent a group of chaperones which protects the cells against a diversity of stresses. It has been demonstrated that hsp27 is constitutively present in cells where it plays an important role in different cytoprotective processes which ultimately inhibit cell death. We investigated the response of the isolated perfused mouse heart over expressing hsp27 to the ischaemia/reperfusion injury using infarct size as an end point. Our results show for the first time that mice over expressing hsp27 (verified by Western blotting analysis) were found to be protected from lethal ischaemia/reperfusion injury compared to their negative littermates.