Details

Autor(en) / Beteiligte

• Gozal, David
• Sans Capdevila, Oscar
• McLaughlin Crabtree, Valerie
• Serpero, Laura D
• Witcher, Lisa A
• Kheirandish-Gozal, Leila

Titel

Plasma IGF-1 levels and cognitive dysfunction in children with obstructive sleep apnea

Ist Teil von

• Sleep medicine, 2009-02, Vol.10 (2), p.167-173

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2009

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Abstract Background Pediatric OSA is associated with substantial morbidity in cognitive function. However, for any given OSA severity level, altered cognitive performance may or may not be present. Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity. Methods Consecutive habitually snoring and non-snoring children ages 5–7 years were recruited from the community, and underwent overnight polysomnography, and neurocognitive testing and a blood draw the next morning. Snoring children were divided into OSA or no OSA, and OSA children were further subdivided into those with ⩾2 abnormal cognitive subtests and into those with normal cognitive scores. Plasma levels of IGF-1 were also measured using ELISA. Results Among snoring children without OSA, circulating IGF-1 was 910 ± 110 pg/mL compared with 1070 ± 240 pg/mL in those with OSA ( p < 0.01). However, IGF-1 was 540 ± 70 pg/mL in children with OSA and cognitive deficits, compared to 1370 ± 170 μg/L in children with OSA and normal cognitive scores ( p < 0.001). Conclusions IGF-1 levels are higher in children with OSA, particularly in those who do not manifest neurocognitive deficits, suggesting that the magnitude of the IGF-1 response elicited by OSA may play a significant protective role against the neurocognitive dysfunction associated with OSA.