Details

Autor(en) / Beteiligte

• IMAMURA, Toshihiko
• MATSUO, Satoshi
• HIBI, Shigeyoshi
• IMASHUKU, Shinsaku
• YOSHIHARA, Takao
• CHIYONOBU, Tomohiro
• MORI, Kanako
• ISHIDA, Hiroyuki
• NISHIMURA, Yasutaka
• KASUBUCHI, Yasuo
• NAYA, Mayumi
• MORIMOTO, Akira

Titel

Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation

Ist Teil von

• International journal of hematology, 2004-08, Vol.80 (2), p.186-189

Ort / Verlag

Tokyo: Springer

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the cervical lymph nodes, tonsils, and adenoids that was manifested as granulocytic sarcoma. Following chemotherapy, the patient underwent a conditioning regimen of busulfan, cyclophosphamide, and total body irradiation followed by successful allogeneic bone marrow transplantation from her single HLA locus-mismatched mother at 6 months after her diagnosis. The patient continues to be well and in remission 3 years after stem cell transplantation.