Current opinion in neurobiology, 2004-10, Vol.14 (5), p.582-588
2004
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- Autor(en) / Beteiligte
- Titel
- Amyloid-beta precursor protein processing in neurodegeneration
- Ist Teil von
- Current opinion in neurobiology, 2004-10, Vol.14 (5), p.582-588
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The amyloid-β precursor protein is proteolytically cleaved by secretases, resulting in a series of fragments, including the amyloid-β peptide of Alzheimer's disease. The amyloid precursor protein, when membrane anchored, could operate as a receptor. After cleavage, the soluble ectodomain exerts a trophic function in the subventricular zone. The amyloid-β peptide itself has a depressant role in synaptic transmission, with both physiological and pathological implications. During the past two years, much time has been invested in determining the molecular pathways that regulate the processing and the signal transduction of the amyloid precursor protein. However, the absence of consistent and informative phenotypes in different loss of function animal models make elucidating the molecular actions of the amyloid-β precursor protein an ongoing challenge.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0959-4388eISSN: 1873-6882DOI: 10.1016/j.conb.2004.08.001Titel-ID: cdi_proquest_miscellaneous_66937614
- Format
- –
- Schlagworte
- Alzheimer Disease - genetics, Alzheimer Disease - metabolism, Amyloid beta-Peptides - genetics, Amyloid beta-Peptides - metabolism, Amyloid beta-Protein Precursor - genetics, Amyloid beta-Protein Precursor - metabolism, Amyloid Precursor Protein Secretases, Animals, Aspartic Acid Endopeptidases, Brain - metabolism, Brain - physiopathology, Cell Membrane - metabolism, Endopeptidases - metabolism, Humans, Mutation - genetics, Nerve Degeneration - metabolism, Neurons - metabolism, Protein Structure, Tertiary - physiology