Details

Autor(en) / Beteiligte

• Pals, Philippe
• Lincoln, Sarah
• Manning, Jonathan
• Heckman, Michael
• Skipper, Lisa
• Hulihan, Mary
• Van den Broeck, Marleen
• De Pooter, Tim
• Cras, Patrick
• Crook, Julia
• Van Broeckhoven, Christine
• Farrer, Matt J.

Titel

α-Synuclein promoter confers susceptibility to Parkinson's disease

Ist Teil von

• Annals of neurology, 2004-10, Vol.56 (4), p.591-595

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2004

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Familial Parkinson's disease (PD) has been linked to missense and genomic multiplication mutations of the α‐synuclein gene (SNCA). Genetic variability within SNCA has been implicated in idiopathic PD in many populations. We now confirm and extend these findings, within a Belgian sample, using a high‐resolution map of genetic markers across the SNCA locus. Our study implicates the SNCA promoter in susceptibility to PD, and more specifically defines a minimum promoter haplotype, spanning approximately 15.3kb of sequence, which is overrepresented in patients. Our findings represent a biomarker for PD and may have implications for patient diagnosis, longitudinal evaluation, and treatment. Ann Neurol 2004;56:591–595