Details

Autor(en) / Beteiligte

• Arredondo-García, José Luis
• Figueroa-Damián, Ricardo
• Rosas, Alejandro
• Jáuregui, Arturo
• Corral, Mauricio
• Costa, Alexis
• Merlos, Roberto Mauricio
• Ríos-Fabra, Antonio
• Amábile-Cuevas, Carlos F.
• Hernández-Oliva, Gerardo M.
• Olguín, Jorge
• Cardeñosa-Guerra, Oscar

Titel

Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: a randomized, multicentre, open-label, prospective study

Ist Teil von

• Journal of antimicrobial chemotherapy, 2004-10, Vol.54 (4), p.840-843

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2004

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Objective: To compare the bacteriological and clinical efficacy of three treatments for uncomplicated cystitis in ambulatory pre-menopausal women: ciprofloxacin 250 mg orally twice daily for 3 days, trimethoprim/sulfamethoxazole 160/800 mg orally twice daily for 7 days, and norfloxacin 400 mg orally twice daily for 7 days. Materials and methods: A total of 455 women were randomly assigned to three treatment groups: 151 received ciprofloxacin, 150 received trimethoprim/sulfamethoxazole, and 154 received norfloxacin. Bacteriological cure and clinical resolution were evaluated 5–9 days and 4–6 weeks after completion of treatment. Results: There was no significant difference among the three treatment groups: overall efficacy ranged from 78.5% for the trimethoprim/sulfamethoxazole group, to 84.5% for the ciprofloxacin group. The highest overall incidence of drug-related adverse effects occurred in the trimethoprim/sulfamethoxazole patients. Conclusions: These data indicate that a 3 day treatment with ciprofloxacin is at least as clinically and bacteriologically effective as 7 day treatments with trimethoprim/sulfamethoxazole and norfloxacin for uncomplicated lower urinary tract infections.