Details

Autor(en) / Beteiligte

• STREUBEL, B
• SIMONITSCH-KLUPP, I
• FORMANEK, M
• ASSANASEN, T
• MÜLLER-HERMELINK, H-K
• CERRONI, L
• RADERER, M
• CHOTT, A
• MÜLLAUER, L
• LAMPRECHT, A
• HUBER, D
• SIEBERT, R
• STOLTE, M
• TRAUTINGER, F
• LUKAS, J
• PÜSPÖK, A

Titel

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

Ist Teil von

• Leukemia, 2004-10, Vol.18 (10), p.1722-1726

Ort / Verlag

London: Nature Publishing

Erscheinungsjahr

2004

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11;18)(q21;q21), t(14;18)(q32;q21), and t(1;14)(p22;q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11;18)(q21;q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14;18)(q32;q21) was most commonly found in lesions of the ocular adnexa/orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.