Details

Autor(en) / Beteiligte

• KELAIDI, C
• ROLLOT, F
• DREYFUS, F
• PARK, S
• TULLIEZ, M
• CHRISTOFOROV, B
• CALMUS, Y
• PODEVIN, P
• BOUSCARY, D
• SOGNI, P
• BLANCHE, P

Titel

Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas

Ist Teil von

• Leukemia, 2004-10, Vol.18 (10), p.1711-1716

Ort / Verlag

London: Nature Publishing

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• A link between chronic hepatitis C virus (HCV) infection and low-grade B-cell lymphomas has been suggested by epidemiological studies. Marginal zone lymphomas (MZLs) including splenic lymphomas with villous lymphocytes are among the most frequently reported subgroups in the setting of chronic HCV infection. In this study, we examined the effect of antiviral treatment in eight patients with HCV-associated MZL. We found that five out of eight patients have responded to interferon alpha and ribavirin. In some cases, hematologic responses were correlated to virologic responses. In addition, we report a case of large granular lymphocyte leukemia occurring in association with MZL and HCV, and responding to interferon and ribavirin. We suggest that there is an etiologic link between HCV and antigen-driven lymphoproliferative disorders.