Details

Autor(en) / Beteiligte

• Grimm, Simone
• Boesiger, Peter
• Beck, Johannes
• Schuepbach, Daniel
• Bermpohl, Felix
• Walter, Martin
• Ernst, Jutta
• Hell, Daniel
• Boeker, Heinz
• Northoff, Georg

Titel

Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects

Ist Teil von

• Neuropsychopharmacology (New York, N.Y.), 2009-03, Vol.34 (4), p.932-943

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Patients with major depressive disorder (MDD) show emotional-cognitive disturbances, which have been associated with alterations within the default-mode network. However, it remains unclear whether these default-mode network alterations are related to abnormalities in NBRs. We therefore investigated neural activity in the default-mode network during different emotional tasks in patients with MDD in an event-related fMRI design. MDD patients showed significantly reduced NBRs in several regions of the default-mode network. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. In sum, our findings demonstrate that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.