Cancer letters, 2009-03, Vol.275 (2), p.194-197
2009
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- Autor(en) / Beteiligte
- Titel
- Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma
- Ist Teil von
- Cancer letters, 2009-03, Vol.275 (2), p.194-197
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration in genomic Grap-2 sequence. Consistent Grap-2 expression suggests a specific role for this adaptor in human MTC, while qualitative alterations do not appear to influence RET signaling.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2008.10.010Titel-ID: cdi_proquest_miscellaneous_66903160
- Format
- –
- Schlagworte
- Adaptor Proteins, Signal Transducing - genetics, Adaptor Proteins, Signal Transducing - metabolism, Base Sequence, Cancer, Carcinoma, Medullary - genetics, Deoxyribonucleic acid, DNA, DNA Primers, Expression, Hematology, Oncology and Palliative Medicine, Humans, Kinases, Mutation, Oncogene, Protein expression, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - genetics, Signal Transduction, Thyroid, Thyroid cancer, Thyroid Neoplasms - genetics, Tyrosine kinase