Experimental neurology, 2004-10, Vol.189 (2), p.413-421
2004
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- Autor(en) / Beteiligte
- Titel
- NMDA receptors in the anterior cingulate cortex mediate pain-related aversion
- Ist Teil von
- Experimental neurology, 2004-10, Vol.189 (2), p.413-421
- Ort / Verlag
- Amsterdam: Elsevier Inc
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Using a rat formalin-induced conditioned place avoidance (F-CPA) model and Fos immunohistochemistry, the present study observed the effect of N-methyl- d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-isoxozole propionic acid/kainite (AMPA/KA) receptors on pain-related aversion. Adult Sprague–Dawley rats were implanted with cannula in the anterior cingulate cortex (ACC) or the lateral ventricle. Before (10 min) the injection of formalin into a hindpaw on days 2 and 4 of place-conditioning trials, vehicle (0.01 M PBS), the NMDA receptors antagonist, 2-amino-5-phosphonovalerate (AP5), or the AMPA/KA receptors antagonist, 6,7-dinitroquinoxaline-2,3-dione (DNQX), was injected through the cannula. F-CPA was effectively eliminated by both intracerebroventricular (icv) and intra-ACC microinjection of AP5. In contrast, the intra-ACC or icv injection of DNQX failed to alter the conditioning scores of F-CPA compared with vehicle control group ( P > 0.05). Intra-ACC or icv injection of AP5 or DNQX had no effect on formalin-induced acute nociceptive behaviors. Fos immunoreactivity in the ACC was activated by retrieval of pain-related aversion, and this activation was significantly suppressed by preadministration of AP5, but not DNQX ( P < 0.001). These results suggest that NMDA receptors in the ACC are preferentially involved in the processing of the affective dimension of pain.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-4886eISSN: 1090-2430DOI: 10.1016/j.expneurol.2004.06.012Titel-ID: cdi_proquest_miscellaneous_66893059
- Format
- –
- Schlagworte
- ACC, AMPA/KA receptors, Animals, Avoidance Learning - drug effects, Avoidance Learning - physiology, Biochemistry and metabolism, Biological and medical sciences, Central nervous system, CPA, Emotions - drug effects, Emotions - physiology, Excitatory Amino Acid Antagonists, Fos, Fundamental and applied biological sciences. Psychology, Glutamic Acid - metabolism, Gyrus Cinguli - metabolism, Immunohistochemistry, Intracerebroventricular injection, Male, Medical sciences, NMDA receptors, Nociceptors - physiology, Orthopedic surgery, Pain - metabolism, Pain - physiopathology, Pain Measurement, Pain-related aversion, Proto-Oncogene Proteins c-fos - metabolism, Rat, Rats, Rats, Sprague-Dawley, Reaction Time - drug effects, Reaction Time - physiology, Receptors, AMPA - antagonists & inhibitors, Receptors, AMPA - metabolism, Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors, Receptors, N-Methyl-D-Aspartate - metabolism, Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases, Synaptic Transmission - drug effects, Synaptic Transmission - physiology, Vertebrates: nervous system and sense organs