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Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering
Journal of biomedical materials research, 2004-10, Vol.71B (1), p.144-152
Boland, Eugene D.
Telemeco, Todd A.
Simpson, David G.
Wnek, Gary E.
Bowlin, Gary L.
2004
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Boland, Eugene D.
Telemeco, Todd A.
Simpson, David G.
Wnek, Gary E.
Bowlin, Gary L.
Titel
Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering
Ist Teil von
Journal of biomedical materials research, 2004-10, Vol.71B (1), p.144-152
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2004
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Poly(glycolic acid) (PGA) has a long history as a bioresorbable polymer. Its biocompatibility is widely accepted, yet PGA is often rejected as a soft‐tissue scaffold because of fibrous encapsulation. The goal of this study was to improve the soft‐tissue biocompatibility of PGA by producing scaffolds composed of small‐diameter fibers through electrospinning and subjecting these scaffolds to a concentrated hydrochloric acid (HCL) pretreatment. The theory is that small‐diameter fibers will elicit a reduced immune response and HCl treatment will improve cellular interactions. Scaffolds were characterized in terms of fiber diameter and pore area via image‐analysis software. Biocompatibility was assessed through a WST‐1 cell‐proliferation assay (in vitro) with the use of rat cardiac fibroblasts and rat intramuscular implantations (in vivo). Fibers produced ranged in diameter from 0.22 to 0.88 μm with pore areas from 1.84 to 13.22 μm2. The untreated scaffold composed of 0.88‐μm fibers was encapsulated in vivo and supported the lowest rates of cell proliferation. On the contrary, the acid pretreated scaffold with 0.22‐μm fibers was incorporated into the surrounding tissue and exhibited proliferation rates that exceeded the control populations on tissue‐culture plastic. In conclusion, this study has shown the ability to improve the biocompatibility of PGA through acid pretreatment of scaffolds comprised of submicron fiber diameters. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 144–152, 2004
Sprache
Englisch
Identifikatoren
ISSN: 1552-4973, 0021-9304
eISSN: 1552-4981
DOI: 10.1002/jbm.b.30105
Titel-ID: cdi_proquest_miscellaneous_66876066
Format
–
Schlagworte
Animals
,
biocompatibility
,
Biocompatible Materials
,
electrospinning
,
Male
,
Materials Testing
,
Microscopy, Electron, Scanning
,
poly(glycolic acid)
,
Polyglycolic Acid - chemistry
,
Prostheses and Implants
,
Rats
,
scaffold
,
tissue engineering
,
Tissue Engineering - methods
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