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Three Metabolites from the Mangrove Endophytic Fungus Sporothrix sp. (#4335) from the South China Sea
Ist Teil von
Journal of organic chemistry, 2009-02, Vol.74 (3), p.1093-1098
Ort / Verlag
Washington, DC: American Chemical Society
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
Three metabolites, sporothrins A, B, and C (1−3), were isolated from the mangrove endophytic fungus Sporothrix sp. (#4335). Their structures were identified by the spectral data and X-ray diffractive techniques, with compound 1 showing strong inhibition of acetylcholine esterase. 1,3,6,8-Tetrahydroxynaphthalene (T4HN) was deduced as one of the precursors in the biosynthesis of 1 and 2. In a primary biosynthesis gene study, the partial gene fragment obtained with the LC1-Im/2c-Im primer pair was shown to be closely related to genes encoding T4HN synthase. The deduced protein sequences were highly homologous to the ketosynthase domains of other fungal PKS genes involved in T4HN biosynthesis.